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FLASH GENE
Symbol SLC39A6 contributors: - updated : 31-01-2006
HGNC name solute carrier family 39 (zinc transporter), member 6
HGNC id 18607
DNA
TYPE functioning gene
STRUCTURE 20.86 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC147354 18q12.1 similar to additional sex combs like 2; polycomb group protein ASXH2 KIAA1713 18q11 KIAA1713 protein NOL4 18q12 nucleolar protein 4 DTNA 18q12.1-q12.2 dystrobrevin, alpha LOC390849 18 similar to ribosomal protein L10a MAPRE2 18q12 microtubule-associated protein, RP/EB family, member 2 ZNF397 18q12.1 zinc finger protein 397 ZNF271 18q12 zinc finger protein 271 ZNF24 18q12 zinc finger protein 24 (KOX 17) ZNF396 18p12 zinc finger protein 396 LOC125476 18q12.2 hypothetical protein LOC125476 GALNT1 18q12.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) LOC388473 18 LOC388473 PNAS-131 18q12.2 hypothetical protein PNAS-131 P15RS 18q12.2 hypothetical protein FLJ10656 SLC39A6 18q12.2 solute carrier family 39 (zinc transporter), member 6 STATIP1 18q12.1 signal transducer and activator of transcription 3 interacting protein 1 MOCOS 18q12 molybdenum cofactor sulfurase RNU4P3 18q12.2 RNA, U4 small nuclear pseudogene 3 LOC390850 18 similar to RIKEN cDNA 0610008N23 KIAA1695 DKFZP586M1523 KIAA1328 18q12.2 KIAA1328 protein BRUNOL4 18q12 bruno-like 4, RNA binding protein (Drosophila)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3637 - 755 - -
8 - 1681 - 433 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrine    
Hearing/Equilibriumearinnercochlea  
Nervousbrainbasal nucleicorpus callosum  
 brainhindbraincerebellum  
 braindiencephalonhypothalamus  
Reproductivefemale systemplacenta   
 female systembreast   
 male systemtestis   
 male systemprostate   
Urinarykidney    
cell lineage
cell lines HeLa and lung carcinoma
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential metalloprotease motif (HEX P H E XGD), which fits the consensus sequence for the catalytic zinc-binding site motif of the zincin metalloproteases
  • two histidine-rich sequences
  • a HELP domain
  • HOMOLOGY
    interspecies ortholog to murine Slc39a6
    homolog to dog liv-1
    ortholog to rattus Slc39a6_predicted
    Homologene
    FAMILY
  • ZIP transporter (tc 2.a.5) family
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • may be a suitable prognostic marker for lymph-node involvement and a key determinant of metastatic spread in steroid hormone receptor-positive disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be a zinc transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by oestrogen treatment
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oestrogen-positive breast cancer with metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS