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FLASH GENE
Symbol SLC36A4 contributors: mct - updated : 30-03-2022
HGNC name solute carrier family 36 (proton/amino acid symporter), member 4
HGNC id 19660
DNA
TYPE functioning gene
STRUCTURE 241.86 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 6037 - 504 - 2011 21097500
11 - 6029 - 369 - 2011 21097500
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuteruscervix  
Visualeye     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text eye,trabecular meshwork ,placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY proton amino acid transporter 4 family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • predominantly associated with the Golgi apparatus in a range of cell types
  • basic FUNCTION
  • having amino acid-polyamine transporter activity
  • is a high-affinity transporter for proline and tryptophan
  • is a very high affinity/low capacity non-proton-coupled amino acid transporter
  • regulates the amino acid pool in the lysosomes of retinal pigmented epithelium (RPE)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB12 promotes constitutive degradation of SLC36A4, whose accumulation in RAB12-knockdown cells modulates MTOR activity and autophagy
  • RAB12 regulates MTOR activity and autophagy through controlling SLC36A4 trafficking from recycling endosomes to lysosomes, where SLC36A4 is degraded
  • interacts with both MTOR and its regulator RAB1A on the Golgi
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisualretina
    CRYBA1/SLC36A4/V-Atpase complex is a potential therapeutic target for preventing or delaying the progression of dry age‐related macular degeneration (AMD)
    ANIMAL & CELL MODELS