Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC17A8 contributors: mct - updated : 02-04-2008
HGNC name solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
HGNC id 20151
DNA
TYPE functioning gene
STRUCTURE 64.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3838 - 589 - Almqvist (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Nervousbrainhindbrainmedulla oblongata  
 braindiencephalonamygdala  
 gangliasensory gangliadorsal root   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 8 membrane-spanning segments and
  • a long C terminus, similar to SLC17A7 and SLC17A6
  • HOMOLOGY
    intraspecies homolog to SLC17A7,SLC17A6
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells
  • functioning as a vesicular glutamate transporter
  • specifically involved in a functional facet of cholinergic interneurons, acetylcholine release
  • responsible for vesicular glutamate storage and exocytotic glutamate release in neurons and astrocytes
  • both SLC17A8 and the cytosolic concentration of glutamate are key limiting factors in regulating the Ca2+-dependent release of glutamate from astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA25
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    induced a hypocholinergic phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target appealing pharmacological target for selectively and moderately reducing striatal cholinergic tone
    ANIMAL & CELL MODELS