protein
| bind to the active Ras oncogene product |
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interacts with the tyrosine kinase LCK through its C-terminal Src homology 2 binding motif and LCK-mediated phosphorylation is critical for the efficient translocation of RASSF5 into the nuclear compartment |
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interacts strongly with MST1 but only weakly with other components of the mammalian Hippo signaling pathway |
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binds directly to the ITGB2 alpha chain cytoplasmic tail |
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interacting with SKAP1 (needed for RASSF5 binding to membranes in a manner dependent on the PH domain of SKAP1 and the PI3K pathway) |
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connection between SKAP1-RASSF5-TERF2IP and the PI3K pathway |
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can act as an inhibitor or a potential positive regulator of STK3, depending on whether it binds to STK3 before or after activation-loop phosphorylation |
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specific activation of RAP1B contributes to neuronal polarization via interaction with RALA and RASSF5 in addition to PI3-kinase |
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two effectors of RAP1A regulate integrins, RASSF5 and APBB1IP |
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UBE2I acts as a functional binding partner of FYB1 and plays a selective role in integrin-mediated T cell adhesion via modulation of RAP1A-RASSF5 membrane recruitment and RAC1 activation |
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RASSF5, is the key downstream target of TET1, and TET1 promotes RASSF5 expression by demethylating a CpG site within RASSF5 promoter |