basic FUNCTION
| WD40-repeat containing protein, that is a common binding partner of WDR48, USP12, and USP46) (Kee 2010) |
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stimulated the enzymatic activity of USP12·WDR48, but not of USP1·WDR48 (Kee 2010) |
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not involved in regulating the FA pathway (Kee 2010) |
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acting as a cofactor that is required for the full enzymatic activity of the USP12·WDR48 DUB complex (Kee 2010) |
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serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1·USP complexes (Kee 2010) |
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potential importance of the USP12/WDR48/WDR20 complex in AR regulation and prostate cancer progression |
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new regulator of the ERAD machinery |
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plays a crucial role in as a "targeting subunit" that modulates CRM1-dependent shuttling of the USP12/WDR48/WDR20 complex between the plasma membrane, cytoplasm and nucleus |