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FLASH GENE
Symbol FAT3 contributors: mct - updated : 30-10-2015
HGNC name FAT tumor suppressor homolog 3 (Drosophila)
HGNC id 23112
DNA
TYPE functioning gene
STRUCTURE 544.37 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 19048 502 4557 - 2012 23076869
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord    
cell lineage
cell lines tumor cell lines
fluid/secretion
at STAGE
physiological period embryo
Text late embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cadherin domain
  • epidermal growth factor (EGF)-like motif
  • a laminin A-G motif and a cytoplasmic domain
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • FAT3 family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing an important role in axon fasciculation and modulation of the extracellular space surrounding axons during embryonic development
  • atypical cadherin FAT3 ensures that amacrine cells develop this unipolar morphology
  • FAT3 and FAT4 synergize potentially to drive vertebral arch fusion at the dorsal midline during caudal vertebra morphogenesis
  • FAT3 and DCHS2 are required for cartilage stacking and polarity, consistent with a role in planar cell polarity (PCP), and are also required for cartilage differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAT3, and its partner DCHS2, control polarized cell-cell intercalation of cartilage precursors during craniofacial development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS