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FLASH GENE
Symbol CD151 contributors: mct/pgu - updated : 01-06-2011
HGNC name CD151 antigen
HGNC id 1630
DNA
TYPE functioning gene
STRUCTURE 5.88 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1574 - 253 - 1997 9070943
8 - 1512 - 253 - 1997 9070943
9 - 1570 - 253 - 1997 9070943
8 - 1508 - 253 - 1997 9070943
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
Nervousbrain     Homo sapiens
Respiratorylung   highly
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
Nervousastrocyte Homo sapiens
Skin/Tegumentkeratinocyte
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four conserved transmembrane domains
  • two extracellular loops and two short cytoplasmic tails
  • a YRSL sequence
  • a YXXphi type of endocytosis/sorting motif, in its C-terminal cytoplasmic domain, playing a key role in signaling
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY TMSF4 family, tetraspanin family
    CATEGORY adaptor , adhesion , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • playing a role in the regulation of cell development, activation, growth and motility
  • functioning as a negative regulator in the adhesion-dependent activation of Ras
  • key component of the glomerular filtration barrier
  • appears to be involved in the establishment, maturation, and/or maintenance of the glomerular basement membrane structure in addition to its role in integrin-mediated adhesion strengthening
  • promotes the formation of epithelial cell-cell contacts in a protein kinase C (PKC) and Cdc42-dependent manner
  • having clearly an important role for HGF-dependent cellular morphogenesis
  • also an important regulator of the stability of tumor cell-cell interactions, potentially through its interaction with alpha3beta1 integrin
  • new role of CD151 in tumorigenesis, whereby it functions as an important regulator of communication between tumor cells and endothelial cells
  • implicated in the regulation of cell-substrate adhesion and cell migration through physical and functional interactions with integrin receptors
  • controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion
  • 'adaptor' between integrins and signal pathways
  • may plays a specific role in promoting prostate cancer cell motility
  • role in maintenance of the specification state in the trigeminal placode, uncovering the first known role for a tetraspanin in a developmental system
  • implicated in cancer progression and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of hemidesmosomes that anchor epithelial cells to basal lamina
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically associates with integrins (ITGA3B1, ITGA5B1, ITGA6B4)
  • ZDHHC2 associated with CD9 and CD151, but not other cell surface proteins, and protected CD151 and CD9 from lysosomal degradation
  • RNF128 bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues
  • interacts predominantly with integrins, which is thought to regulate the in
  • out signaling
  • physical association between CD151 and c-Met points to a potential adjunctive function of CD151 in HGF/c-Met signaling
  • cell & other
    REGULATION
    induced by HTLV1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    associated with advanced stage and high nuclear grade in clear cell renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic marker for tumour progression in clear cell renal cell carcinoma patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may be useful as a high-priority therapeutic target for antiangiogenesis in hepatocellular carcinoma
    cancerreproductivebreast
    potentially novel prognostic marker and target for therapy in breast cancer
    ANIMAL & CELL MODELS
  • Cd151-null murine kidneys were severe alterations of the glomerular basement membrane (GBM), reminiscent of Alport syndrome and consisting of massive thickening and splitting of the GBM