basic FUNCTION
| involved in protein modification, ubiquitin cycle |
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HECTD1 function is required at a critical threshold for neural tube closure |
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is a functional ubiquitin ligase |
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HECTD1 promotes the APC-AXIN1 interaction to negatively regulate WNT signaling |
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is required for development of multiple cell types within the junctional zone of the placenta |
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is involved in ABCA1-mediated cholesterol export from macrophages |
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control of MACF1 levels by HECTD1 modulates likely epithelial-to-mesenchymal transition (EMT) and the efficiency of metastasis |
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HECTD1 is a mammalian E3 ligase that assembles branched K29/K48 chains |