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FLASH GENE
Symbol RTF1 contributors: mct - updated : 17-04-2014
HGNC name Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
HGNC id 28996
DNA
TYPE functioning gene
STRUCTURE 66.46 kb     18 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 5038 - 710 - 2006 16882721
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central region called the ORF-Association Region (OAR) was shown to be required for recruitment of PAF1C to chromatin, conserved domain also named the Plus3 domain after the presence of three invariant positively charged amino acids
  • a C-domain with unexpected similarity to the Ras family of small GTPases
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • RTF1 component of the PAF1 complex functions in NOTCH signaling
  • LEO1, but not RTF1, is necessary for the complex to bind RNA
  • RTF1, CDC73, and LEO1 have all been shown to play a role in recruitment of PAF1C to chromatin at active genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • loss of either RTF1 or CDC73 results in the detachment of the PAF1 complex from Pol II and the chromatin form of actively transcribed genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS