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FLASH GENE
Symbol NKAPL contributors: mct - updated : 04-04-2022
HGNC name NFKB activating protein-like
HGNC id 21584
DNA
TYPE functioning gene
STRUCTURE 1.66 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1662 46 402 - 2015 25875095
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte Homo sapiens
Reproductivespermatogonia Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • germ cell-specific transcriptional suppressor in Notch signaling
  • is indispensable because aberrantly elevated NOTCH signaling has negative effects on spermatogenesis, affecting spermatogonial stem cell (SSC) maintenance and differentiation factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NOTCH signaling should be properly regulated through the transcriptional factor NKAPL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other
  • rs1635 in the NKAPL gene appeared to play a role in conferring susceptibility to schizophrenia
  • Candidate gene
    Marker
  • potential diagnostic and prognostic markers in triple-negative breast cancer
  • methylation of NKAPL is a frequent event and is a potential prognosis biomarker in Hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
  • Nkapl-deleted mice showed complete arrest at the level of pachytene spermatocytes