Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | AP2S1 | contributors: mct - updated : 24-01-2023 |
HGNC name | adaptor-related protein complex 2, sigma 1 subunit |
HGNC id | 565 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 12.68 kb 4 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
mono polymer | heteromer , tetramer |
HOMOLOGY |
Homologene |
FAMILY | clathrin adaptor complexes small chain proteins family |
CATEGORY | adaptor |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endosome | |
intracellular,cytoplasm,organelle,lysosome | |
intracellular,cytoplasm,cytosolic,vesicle | |
text | cytoplasmic face of coated vesicles |
basic FUNCTION | |
| |
| |
8208;mediated endocytosis of G& | |
8208;protein–coupled receptors (GPCR) such as the CASR |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
| |
(alpha1A/AP2A1 or alpha1B/AP2A1 or alpha2/AP2A2 and beta1/AP2B1), a medium adaptin (mu2/AP2M1) and | |
a small adaptin (sigma2long/AP2S1 or sigma2short/AP2S1) |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | HHC3 |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |