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FLASH GENE
Symbol CENPQ contributors: mct/pgu - updated : 08-02-2013
HGNC name centromere protein Q
HGNC id 21347
DNA
TYPE functioning gene
STRUCTURE 29.72 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1753 31 268 - 2011 21454580
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one putative coiled-coil domain (which does not correspond to a leucine zipper) from AA 155 to 203
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • MLF1IP and CENPQ are mutually required to localize to interphase and mitotic centromeres
  • phosphoregulation of CENPQ plays a central function in coordinating chromosome congression mechanisms (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constitutive centromere-associated network (CCAN) component
  • MLF1IP forms a binary complex with CENPQ, to promote their mutual stability and subcellular localization to interphase and mitotic centromeres
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLF1IP directly interacts with CENPQ, and this interaction was mutually required not only for their stability but also for their centromere localization
  • targets PLK1 to kinetochores and is also required for the recruitment of CENPE to kinetochores
  • cell & other
    REGULATION
    Phosphorylated by MLF1IP-bound PLK1 phosphorylates CENPQ
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS