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FLASH GENE
Symbol ATAT1 contributors: mct - updated : 14-05-2014
HGNC name alpha tubulin acetyltransferase 1
HGNC id 21186
DNA
TYPE functioning gene
STRUCTURE 19.99 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1740 - 409 - 1997 9373149
11 - 2195 - 323 - 1997 9373149
9 - 2875 - 288 - 1997 9373149
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineadrenal gland   highly
Nervousbrainforebraincerebral cortex highly Rattus norvegicusFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain (AAs 1–193)
  • an unstructured tail (AAs 193–421)
  • AP2-binding region (AAs 307–387) pulled down full-length alpha-adaptin and a truncated variant lacking the appendage domain (AAs 1–690), but not a construct missing both the hinge and appendage domains (AAs 1–620)
  • HOMOLOGY
    Homologene
    FAMILY
  • UPF0635 family
  • CATEGORY enzyme , motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • colocalizes on bundled microtubules with doublecortin
  • localizes to clathrin-coated pits (CCPs) through a direct interaction with AP2 that is required for microtubule acetylation
  • basic FUNCTION
  • enzyme that acetylates the K40 residue of alpha-tubulin, the only post-translational modifications known to occur on the luminal surface of microtubules
  • could acetylate another protein, or act as a MAP, possibly inside the microtubule lumen
  • having a highly specific alpha-tubulin K40 acetyltransferase activity and a catalytic preference for microtubules over free tubulin
  • promotes rapid ciliogenesis and efficient mechanosensation
  • required for the acetylation of axonemal microtubules and for the normal kinetics of primary cilium assembly
  • balance of acetylation and deaceylation by ATAT1/HDAC6 enzymes with opposite activities regulates the migratory and invasive capacities of breast tumor cells
  • importance of ATAT1 and alpha-tubulin acetylation in cortical development
  • has an overall fold similar to the KAT2A histone acetyltransferase but contains a relatively wide substrate binding groove and unique structural elements that play important roles in alpha-tubulin-specific acetylation
  • has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATAT1 tubulin acetyltransferase binds and regulates cortactin acetylation levels
  • interaction of ATAT1 with AP2A1, AP2A2, AP2B1, AP2M1 is required for directional migration
  • EP300 negatively regulates ATAT1 expression and is sequestered on microtubules upon stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Atat1-null mices display no overt phenotypes, alpha-tubulin acetylation is lost in sperm flagella and the dentate gyrus is slightly deformed