basic FUNCTION
| enzyme that acetylates the K40 residue of alpha-tubulin, the only post-translational modifications known to occur on the luminal surface of microtubules |
|
could acetylate another protein, or act as a MAP, possibly inside the microtubule lumen |
|
having a highly specific alpha-tubulin K40 acetyltransferase activity and a catalytic preference for microtubules over free tubulin |
|
promotes rapid ciliogenesis and efficient mechanosensation |
|
required for the acetylation of axonemal microtubules and for the normal kinetics of primary cilium assembly |
|
balance of acetylation and deaceylation by ATAT1/HDAC6 enzymes with opposite activities regulates the migratory and invasive capacities of breast tumor cells |
|
importance of ATAT1 and alpha-tubulin acetylation in cortical development |
|
has an overall fold similar to the KAT2A histone acetyltransferase but contains a relatively wide substrate binding groove and unique structural elements that play important roles in alpha-tubulin-specific acetylation |
|
has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules |