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FLASH GENE
Symbol S100A13 contributors: mct/npt - updated : 03-07-2009
HGNC name S100 calcium binding protein A13
HGNC id 10490
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 15.30 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 951 - 98 - Oh, Wicki (1996)
4 - 743 - 98 - Oh, Wicki (1996)
3 - 667 - 98 - Oh, Wicki (1996)
3 - 638 - 98 - Oh, Wicki (1996)
3 - 606 - 98 - Oh, Wicki (1996)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
Endocrinepancreas    
Reproductivefemale systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two calcium binding domains with an Ef-hand-motif
  • two characteristic EF-hand domains
  • one S-100 specific Nter, one classical Cter
  • HOMOLOGY
    Homologene
    FAMILY
  • S-100 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text under stress, FGF1 and S100A13 colocalize at the plasma membrane (Graziani 2009)
    basic FUNCTION
  • involved in the regulation of FGF1 and SYT1 release in response to temperature stress
  • plays an important role in the secretion of FGF1 and interleukin 1alpha, two pro-angiogenic factors released by the endoplasmic reticulum/Golgi-independent non-classical secretory pathway (Imai 2006)
  • copper binding protein able to enhance the export of FGF1 in response to stress and to induce the formation of a multiprotein aggregate responsible for FGF1 release (Landriscina 2006)
  • calcium binding protein, known to participate in the non-classical secretion of signal peptide-less proteins, such as the acidic fibroblast growth factor (Kathir 2007)
  • participates also in the stress-dependent nonclassical export of IL1A and specifically associates with FGF1 at stress in glial cells (Graziani 2009)
  • small calcium-binding protein critical for FGF1 export (Graziani 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacting with IL1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of S100A13 and VEGFA expression correlated with the activation of angiogenesis in high-grade astrocytic gliomas (Landriscina 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS