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FLASH GENE
Symbol RTKN2 contributors: mct - updated : 24-01-2009
HGNC name rhotekin 2
HGNC id 19364
DNA
TYPE functioning gene
STRUCTURE 75.50 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D10S2323 - D10S1640 - RTKN2 - D10S1652 - D10S1162 qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 6659 - 609 - Collier (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Reproductivemale systemprostate   
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
cell cycle     cell cycle
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a class I Rho-binding domain
  • a pleckstrin homology (PH) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION may play an important role in lymphopoiesis (Collier 2004)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein target peptides (effectors) for the Rho-GTPases (Collier 2004)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to uric acid nephrolithiasis (see UAN)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS