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FLASH GENE
Symbol CHAMP1 contributors: npt/shn - updated : 14-10-2015
HGNC name chromosome alignment maintaining phosphoprotein 1
HGNC id 20311
DNA
TYPE functioning gene
STRUCTURE 12.84 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - D13S1295 - D13S293 - ZNF828 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 3792 88.9 812 - 2015 2634033
3 splicing 3828 - 812 - 2015 2634033
3 splicing 3831 - 812 - 2015 2634033
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three characteristic repeat motifs termed the WK, SPE, and FPE motifs, responsible for spindle and kinetochore localization, and essential for proper chromosome alignment
  • C-terminal region containing the zinc-finger domains negatively regulates chromosome alignment, and phosphorylation in the FPE region counteracts this regulation
  • HOMOLOGY
    interspecies ortholog to ZNF828, Pan troglodytes
    ortholog to Zfp828, Mus musculus
    Homologene
    FAMILY
  • zinc finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes to chromosomes and the spindle including kinetochores
  • basic FUNCTION
  • required for maintaining kinetochore-microtubule attachment during bi-orientation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates localization of CENPE and CENPF to kinetochores
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD40
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • ZNF828-depleted cells showed severe chromosome misalignment associated with the poor resistance of K-fibres to the tension exerted upon establishment of sister kinetochore bi-orientation (