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FLASH GENE
Symbol ASB9 contributors: mct - updated : 15-04-2015
HGNC name ankyrin repeat and SOCS box-containing 9
HGNC id 17184
DNA
TYPE functioning gene
STRUCTURE 26.48 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1962 - 262 - 2012 22418839
  • HASB9-2
  • one ankyrin repeat domain
  • first six ankyrin repeats along with the N-terminal region of hASB9-2 contribute to the interaction with CKB
  • 7 - 1745 - 252 - 2012 22418839
    7 - 1714 - 294 - 2012 22418839
    7 - 1775 - 262 - 2012 22418839
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six N terminal ankyrin (ANK) repeats
  • a conserved C-terminal SOCS box motif
  • HOMOLOGY
    interspecies homolog to murine Asb9
    Homologene
    FAMILY
  • ankyrin repeat and SOCS box-containing (ASB) family of proteins
  • SOCS box (ASB) family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • facilitates the polyubiquitination of CKB to mediate proteasomal degradation through the SOCS box domain
  • CELLULAR PROCESS protein, post translation, targeting
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • elonguin B/C complex
  • CKB interacts with ASB9 in a specific, SOCS box-independent manner
  • ASB9 interacts with the creatine kinase system and negatively regulates cell growth
  • ankyrin repeat domains of ASB9 can associate with the substrate binding site of CMKT1A in a SOCS box-independent manner
  • specific substrate-recognition subunit of an elongin C-cullin-SOCS box E3 ubiquitin ligase complex
  • ASB9 binds to creatine kinase (CKB) and targets it for degradation
  • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS