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FLASH GENE
Symbol ARHGAP15 contributors: mct - updated : 28-12-2022
HGNC name Rho GTPase activating protein 15
HGNC id 21030
DNA
TYPE functioning gene
STRUCTURE 638.93 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1670 54.4 475 - 2003 12650940
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal and PH domains were able to bind PAK2
  • a novel motif N-terminal to the GAP domain and this novel motif was found to be responsible for nucleotide-independent Rac1 binding
  • a pleckstrin homology (PH) domain
  • a RhoGAP domain
  • HOMOLOGY
    Homologene
    FAMILY RhoGAP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • potential regulator of Rac1
  • is a master negative regulator of neutrophil functions
  • ARHGAP15 plays likely a dual negative role in regulating small GTPase signaling, by acting at the level of the GTPase itself, as well interacting with its effector, PAK2
  • GTPase activating protein which enhances intrinsic hydrolysis of GTP-bound Ras-related C3 botulinus toxin substrate (RAC1), resulting in inactivation of RAC1
  • functions in multiple biological processes, such as cell proliferation and migration
  • ARHGAP15 imposes a fine negative regulation on RAC1 required for morphological maturation and directional control during CIN migration, with consequences on their laminar distribution and inhibitory function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARHGAP15, is a substrate of the Rac effectors PAK1 and PAK2
  • ARHGAP15 is an androgen-induced gene and has anti-tumorigenic roles associated with the RAC1 pathway
  • regulates lung cancer cell proliferation and metastasis via the STAT3 pathway
  • ARHGAP15 is a RAC1-specific GAP expressed during development in a fraction of migrating cortical interneurons (CINs) and in the majority of adult CINs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer tissues and cells
    Susceptibility to chondromalacia
    Variant & Polymorphism SNP
  • rs144449054 in the ARHGAP15 associated with chondromalacia
  • Candidate gene
    Marker
  • ARHGAP15 immunoreactivity is considered a potent prognostic factor in human breast carcinomas
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    ARHGAP15 targeting might be beneficial in specific pathologic settings like severe sepsis
    ANIMAL & CELL MODELS
  • Adult ArhGAP15-/- mice showed defective hippocampus-dependent functions such as working and associative memories