basic FUNCTION
| potential regulator of Rac1 |
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is a master negative regulator of neutrophil functions |
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ARHGAP15 plays likely a dual negative role in regulating small GTPase signaling, by acting at the level of the GTPase itself, as well interacting with its effector, PAK2 |
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GTPase activating protein which enhances intrinsic hydrolysis of GTP-bound Ras-related C3 botulinus toxin substrate (RAC1), resulting in inactivation of RAC1 |
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functions in multiple biological processes, such as cell proliferation and migration |
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ARHGAP15 imposes a fine negative regulation on RAC1 required for morphological maturation and directional control during CIN migration, with consequences on their laminar distribution and inhibitory function |