basic FUNCTION
| may be playing a role in visual proessing in the inner retina or for hippocampal function |
|
PITPNM1, PITPNM2, PITPNM3, PITPNA, PITPNB, PITPNC1 are regulators of phosphoinositide pathways by recruitment to membranes through specific protein interactions to promote molecular exchange between closely opposed membranes i.e., at membrane contact sites |
|
is required in a cellular circuit that transduces light input from rods to bipolar cells that are coupled to GABAergic amacrine cells and ultimately to ipRGCs (intrinsically photosensitive retinal ganglion cells), thereby enabling ipRGCs to respond to dim light |
|
PITPNM1, PITPNM2, work in tandem to achieve different levels of feedback based on the consumption of PM (plasma membrane) Phosphatidylinositol 4,5-Bisphosphate and function at ER-PM junctions to mediate nonvesicular lipid transport between the ER and the PM |