Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FATE1 contributors: mct - updated : 04-01-2012
HGNC name fetal and adult testis expressed 1
HGNC id 24683
DNA
TYPE functioning gene
STRUCTURE 7.16 kb     5 Exon(s)
regulatory sequence Promoter (TATA box)
Binding site   HRE
text structure
  • a putative SF1 binding site in promoter upstream of the transcription start site
  • three elements similar to Wilms tumor antigen-1-binding site consensus sequences
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1071 - 183 - 2003 12865919
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Nervousbrain    
    Reproductivemale systemtestis  predominantly Homo sapiens
    Respiratorylung    
    Urinarykidney    
    cell lineage in tumor tissues (specifically hepatocarcinoma cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text testis specific
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 40-amino acid F-box motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be a target of SF1 in testicular differentiation and/or germ cell development
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its expression is regulated by steroidogenic factor-1 (SF1) and Wilms tumor protein (WT1), two proteins involved in tumorigenesis, suggesting the role of FATE1 in tumor development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS