Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP2R3C contributors: mct - updated : 07-10-2020
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma
HGNC id 17485
DNA
TYPE functioning gene
STRUCTURE 37.19 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1511 53 453 - 2019 30893644
12 - 1383 - 343 - 2019 30893644
13 - 1571 - 343 - 2019 30893644
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  predominantly Homo sapiens
Visualeyeuveachoroid  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two EF-hand domains
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis
  • is a critical intracellular signaling molecule involved in spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPP2R3C negatively regulates ABCB1 expression and function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDRM , SPGF36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS