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FLASH GENE
Symbol DNAJC1 contributors: - updated : 25-07-2006
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 1
HGNC id 20090
DNA
TYPE functioning gene
STRUCTURE 247.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinelarge intestinecolon moderately
 liver   moderately
 stomach   highly
Endocrineparathyroid   highly
 thyroid   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
 respiratory tractlarynx  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text umbilical cord (predominantly)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a J domain
  • a MYB-like DNA binding domain
  • a C-terminal cytosolic region of unknown function consisting of two SANT domains separated by a spacer region
  • HOMOLOGY
    interspecies ortholog to rattus Dnajc1 (86.3pc)
    ortholog to murine Dnajc1 (86pc)
    Homologene
    FAMILY
    CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    text
  • nuclear membrane (multi-pass membrane protein)
  • microsomal membrane (multi-pass membrane protein)
  • endoplasmic reticulum lumen
  • basic FUNCTION
  • acting as an ATPase stimulator
  • acting as a Hsp70/Hsc70 protein regulator
  • involved in the negative regulation of proteolysis
  • playing a role in the regulation of protein secretion
  • playing a role in the regulation of transcription
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • unfolded protein
  • alpha1-antichymotrypsin
  • HSPA5
  • cell & other
  • ribosome
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS