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FLASH GENE
Symbol SEC62 contributors: npt - updated : 24-04-2003
HGNC name SEC62 homolog (S. cerevisiae)
HGNC id 11846
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     8 Exon(s)
regulatory sequence Binding site   transcription factor
text structure Evi-1, GATA, v-Myb, MZF1 and AP-1 binding sites
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text
  • with two transcripts of 2.8 and 5.5 kb (Daimon)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6541 45 399 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   moderately
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila Trp1
    homolog to yeast S.cerevisiae Sec62
    Homologene
    FAMILY
  • SEC62 family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • performing post-translational protein translocation into the ER when involved in Sec61-Sec62-Sec63 complex
  • performing the backward transport of ER proteins subject to the ubiquitin-proteasome-dependent degradation pathway when involved in Sec61-Sec62-Sec63 complex
  • involved in protein transport
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • forming a Sec61-Sec62-Sec63 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to ribosome-free SEC61 complex and SEC63
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS