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FLASH GENE
Symbol APRT contributors: mct/npt - updated : 14-10-2009
HGNC name adenine phosphoribosyltransferase
HGNC id 626
DNA
TYPE functioning gene
STRUCTURE 2.47 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure no TATA, no CCATT, five CpG boxes
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 807 19.4 180 - Taniguchi, Silva (2008)
5 - 673 - 134 - Taniguchi, Silva (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemprostate   
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • phosphoribosyl transferase domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus aprt
    Homologene
    FAMILY
  • purine/pyrimidine phosphoribosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • synthesis of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP)
  • purine salvage pathway
  • important enzyme component of the purine recycling pathway (Silva 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine ribonucleoside salvage
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APRT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS