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FLASH GENE
Symbol YEATS4 contributors: mct - updated : 18-06-2019
HGNC name YEATS domain containing 4
HGNC id 24859
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to S cerevisiae Anc1
ortholog to murine Yeats4
intraspecies homolog to MLLT3,MLLT1
Homologene
FAMILY YEATS family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • having a transcription stimulatory activity
  • involved in regulation of transcription, DNA-dependent
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SWI/SNF complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT1, MLLT3, SMARCB1
  • YEATS4 is a histone acetylation reader that promotes histone H2AFZ deposition in non small cell lung cancer (NSCLC)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in low grade glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS