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FLASH GENE
Symbol SEC16B contributors: mct/npt/pgu - updated : 20-08-2012
HGNC name SEC16 homolog B (S. cerevisiae)
HGNC id 30301
DNA
TYPE functioning gene
STRUCTURE 40.81 kb     26 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 4024 - 1060 - 2007 17192411
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Endocrinepancreas    
Nervousbrainhindbrainmedulla oblongata  
 nervespinal nervesciatic highly
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, lens, anterior segment, retina foveal, macular RPE, choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region is necessary and sufficient for transitional ER localization
  • C-terminal region rich in Gly and Ser, and not conserved in SEC16A (this unique AA composition of the C-terminal region may allow SEC16B to localize to special ER domains, where it modulates the export of PEX16 and PEX3 from the ER)
  • HOMOLOGY
    interspecies homolog to murine Rgpr
    Homologene
    FAMILY
  • SEC16 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the budding of transport vesicle from the endoplasmic reticulum
  • plays a role in membrane traffic from the endoplasmic reticulum
  • role in the biogenesis of mammalian peroxisomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • present at multiple copies in a heteromeric complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays an important role in the transport of PEX16 from the ER to peroxisomes in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism SNP rs10913469 associated to obesity risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS