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FLASH GENE
Symbol TRIM41 contributors: mct - updated : 03-09-2020
HGNC name tripartite motif-containing 41
HGNC id 19013
DNA
TYPE functioning gene
STRUCTURE 12.54 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D5S408 - D5S2006 - TRIM41 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 3645 71.5 630 - 2018 29899090
variant alpha
8 splicing 2705 59.2 518 - 2018 29899090
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousnervecranial nerve  highly
Respiratorylung     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • segment common to both isoforms, but independent of a classical nuclear localization signal sequence
  • a B-box type 2 domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a B30.2/SPRY domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus TRIM41 (94.3 pc)
    homolog to murine Trim41 (94.3 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,nucleolus
    text full-length TRIM41 alpha and TRIM41 beta were both observed as speckles in the cytoplasm and the nucleus
    basic FUNCTION
  • identifying specific cell compartments
  • may function in male germ cell development
  • having DNA-binding activity and preferentially bound to double- stranded DNA
  • acting as a E3 ubiquitin ligase (Chen 2007)
  • endogenous role of TRIM41 in regulating HBV transcription in human hepatoma cells
  • both TRIM52 and TRIM41 have dramatically expanded RING domains compared with the rest of the TRIM multigene family
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component homomultimerizes
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with PKCD (Chen 2007)
  • TRIM41 interacts with IAV Nucleoprotein (NP) through its SPRY domain
  • ZSCAN21 stimulates SNCA transcription in neuronal cells and TRIM41 is an E3 ubiquitin ligase for ZSCAN21
  • TRIM17 and TRIM41 modulate SNCA expression by regulating ZSCAN21
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS