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FLASH GENE
Symbol ZNF318 contributors: - updated : 07-02-2007
HGNC name zinc finger protein 318
HGNC id 13578
DNA
TYPE functioning gene
STRUCTURE 33.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Nervousnervecranial nerve  highly
Reproductivemale systemtestis   
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoptic nerve
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a zinc finger domain of the C2H2 type, two matrin-type zinc fingers
  • four basic amino-acid rich domains
  • a myosin II-homology domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Zfp318
    Homologene
    FAMILY
    CATEGORY structural protein , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional regulator during spermatogenesis in particular, during meiotic division
  • acting as a novel corepressor of AR
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the N-terminal domain of AR (binding to the activation function-1 (AF-1) domain (N-terminal transactivating domain) of AR protein )
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS