SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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| localization within the presynaptic nerve terminal (Stowers 2007) |
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with ZDHHC17, co-localized to the Golgi and the same post-Golgi vesicles, suggesting that heteropalmitoylation might play a physiological role in addition to a biochemical function (Hines 2010) |
basic FUNCTION
| playing a role in intracellular trafficking and endocytosis |
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acting as a protein palmitoyltransferase and having an oncogenic potential |
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palmitoyl transferase involved in the palmitoylation and trafficking of multiple neuronal proteins |
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having palmitoyl acyltransferase activity through innate cysteine-rich domains, DHHC (Goytain 2008) |
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encode Mg2+ transport proteins that are regulated by their innate palmitoyl acyltransferases thus fulfilling the characteristics of "chanzymes", proteins combining transport and enzymatic functions (Goytain 2008) |
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controls neurotransmitter release by regulating the trafficking of cysteine string protein to synapses (Ohyama 2007) |
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is the only ZDHHC gene transcribed in normal human erythroid cells |
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DHHC17, DHHC18, DHHC20, and DHHC21 exhibited weak or moderate activities |
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is critically involved in behavioral modulation of striatal processing |