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FLASH GENE
Symbol TNIP3 contributors: mct/npt - updated : 20-02-2010
HGNC name TNFAIP3 interacting protein 3
HGNC id 19315
DNA
TYPE functioning gene
STRUCTURE 85.09 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2429 - 325 - Staege (2001), Verstrepen (2009)
11 - 2397 - 325 - Staege (2001), Verstrepen (2009)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Reproductivefemale systemuteruscervix  
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three coiled-coil domains
  • an AHD2 region essential for the NF-B inhibiting function of TNIP3
  • an ubiquitin-binding domain that is essential for their NF-kappaB inhibitory and anti-apoptotic activities (Verstrepen 2009)
  • HOMOLOGY
    intraspecies homolog to TNIP2, TNIP3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • negative feedback regulator of LPS-induced NF-B activation
  • having an important role in the development and progress of septic shock and different autoimmune and chronic inflammatory diseases
  • capable of inhibiting NF-kappaB activation in response to signaling from Toll-like receptor, IL1, and tumor necrosis factor (Weaver 2007)
  • IL10-induced gene product capable of attenuating NF-kappaB in human macrophages (Weaver 2007)
  • lipopolysaccharide (LPS)-inducible protein in monocytes that negatively regulates NF-B activation in response to tumour necrosis factor (TNF) and LPS (Verstrepen 2008)
  • important role in the regulation of immunity and tissue homeostasis (Verstrepen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • potential role for the TNFAIP3/ABIN complex in the negative feedback regulation of NF-kappaB activation (Verstrepen 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein bind the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein TNFAIP3 (Verstrepen 2009)
    cell & other
    REGULATION
    induced by induced selectively by IL10 in mononuclear phagocytes coordinately undergoing proinflammatory responses (Weaver 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS