basic FUNCTION
| negative feedback regulator of LPS-induced NF-B activation |
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having an important role in the development and progress of septic shock and different autoimmune and chronic inflammatory diseases |
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capable of inhibiting NF-kappaB activation in response to signaling from Toll-like receptor, IL1, and tumor necrosis factor (Weaver 2007) |
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IL10-induced gene product capable of attenuating NF-kappaB in human macrophages (Weaver 2007) |
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lipopolysaccharide (LPS)-inducible protein in monocytes that negatively regulates NF-B activation in response to tumour necrosis factor (TNF) and LPS (Verstrepen 2008) |
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important role in the regulation of immunity and tissue homeostasis (Verstrepen 2009) |