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FLASH GENE
Symbol CASKIN1 contributors: shn/ - updated : 30-07-2010
HGNC name CASK interacting protein 1
HGNC id 20879
DNA
TYPE functioning gene
STRUCTURE 19.28 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D16S3024 - D16S3395 - CASKIN1 - D16S3124 - D16S3070 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 5695 180 1431 brain 2002 12040031
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific
Reproductivemale systemtestis    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 domain
  • six ankyrin repeats
  • two sterile alpha motif (SAM) domains, that form a new type of SAM helical polymer
  • and a CASK interaction domain (CID)
  • the C terminus contains a long proline-rich sequence and a short conserved domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG12424
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • CASK and CASKIN1 may work together to organize the cytomatrix in active zones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calcium/calmodulin-dependent serine protein kinase (MAGUK family), CASK and Mint 1
  • CASKIN1 and APBA1 interaction with CASK
  • CASK binds to a region of CASKIN1 called the CASK interaction domain (CID)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS