protein
| coexpressed with HNF4A (see also RGHE) in liver |
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coactivating the human lactase-phlorizin hydrolase promoter |
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interacting with SLC23A1 (HNF-1alpha and/or HNF-1beta binding is required for its expression and may be involved in the coordinate regulation of whole body vitamin C status) |
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interacting with NKX6-1 (binds to a cis-regulatory element in the HNF1A promoter and is a major regulator of this gene in pancreatic beta cells |
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can bind to the NPC1L1 promoter |
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directly regulates the expression of CLCN5 in the renal proximal tubule and yield insights into the mechanisms governing epithelial differentiation and specialized transport activities in the kidney |
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HNF1A regulates MAFA in beta-cells, suggesting that compromised MAFA expression contributes to beta-cell dysfunction in maturity onset diabetes of the young |
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interacting with SIRT1 (SIRT1 plays a vital role in the regulation of hepatic bile acid homeostasis through the HNF1A/NR1H4 signaling pathway) |
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YWHAZ may be an endogenous physiologic regulator of HNF1A |
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HNF1A regulates SLC22A1 transcription and contributes to the strong, liver-specific expression of SLC22A1 |
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HNF1A positively regulated CASC2 expression |
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MACF1 promotes osteoblast differentiation by promoting CTNNB1/HNF1A/RUNX2 signaling axis |
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regulates hepatic lipid metabolism by promoting the expression of SOCS3 and negatively regulating the STAT3 signaling pathway |
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HNF1A upregulates transactivation of an anti-apoptotic gene BCL2L1 |