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FLASH GENE
Symbol ZNF397 contributors: mct - updated : 15-02-2011
HGNC name zinc finger protein 397
HGNC id 18818
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with ZNF396
STRUCTURE 17.40 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2644 - 534 widely 2003 12801647
  • also called ZNF397-fu
  • nuclear
  • 6 - 1494 - 275 widely 2003 12801647
  • also called ZNF397-nf
  • nuclear and cytoplasmic
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   moderately
    Reproductivemale systemtestis  highly
     male systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SCAN domain in the N-terminal region, necessary but not sufficient for centromere localisation
  • nine consecutive C(2)H(2) zinc finger repeats in the C-terminal region
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text co-localisation of ZNF397 with the constitutive centromere protein CENPA during interphase and early prophase
    basic FUNCTION
  • may be involved in transcriptional regulation
  • interphase to early prophase-specific and SCAN domain-containing mammalian centromere protein with a possible role in transcription at the centromere
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS