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FLASH GENE
Symbol ST18 contributors: mct/npt - updated : 30/10/2008
HGNC name suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
HGNC id 18695
DNA
TYPE functioning gene
STRUCTURE 298.50 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC137133 8q11.22 similar to phosphoserine aminotransferase isoform 1 LOC389656 8 LOC389656 SNTG1 8q11.2-q12 syntrophin, gamma 1 HCP22 8q11.22 cytochrome c, somatic pseudogene FLJ25471 8q11.22 hypothetical protein FLJ25471 BTF3P1 8q11.22 basic transcription factor 3, pseudogene 1 LOC115294 8q11.22 similar to hypothetical protein FLJ10883 LOC389657 8 LOC389657 ST18 8q11.21 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) LOC389658 8 similar to RPLK9433 RB1CC1 8p22-q11.23 RB1-inducible coiled-coil 1 GPR7 10q11.2-q21.1 G protein-coupled receptor 7 LOC392219 8 similar to ring finger protein 2 OPRK1 8q11.2 opioid receptor, kappa 1 LOC392220 8 similar to L21 ribosomal protein MAPK6PS1 8q11.23 similar to L21 ribosomal protein ATP6V1H 8p22-q22.3 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H RGS20 8q11.22-q11.23 regulator of G-protein signalling 20 TCEA1 3p22-p21.3 transcription elongation factor A (SII), 1 LYPLA1 6pter-p25.1 lysophospholipase I TDGF5 8q11.23 teratocarcinoma-derived growth factor 5, pseudogene MRPL15 8q11.2-q13 mitochondrial ribosomal protein L15 LOC392221 8 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein SOX17 8q11,22 SRY (sex determining region y)-box 17 LOC389659 8 hypothetical gene supported by BC028018 LOC392222 8 similar to RIKEN cDNA 0610038D11
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 6330 115 1047 - Jandrig (2004
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen    
Nervousbrain    
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
Text in the developing CNS
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys)
  • a SMC domain
    • HOMOLOGY
    interspecies ortholog to murine St18
    homolog to rattus St18
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) gene family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressor of tumorogenicity (may be the same than TSG8E)
  • having the potential to act as transcriptional regulator
  • may have a regulatory function in a specific phase during neuronal differentiation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    breast carcinoma
    tumoral     --low  
    a 160 bp region within the promoter is hypermethylated in about 80p100 of the breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS