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FLASH GENE

Symbol

ST18

contributors: mct/npt - updated : 30/10/2008

HGNC name	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
HGNC id	18695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	298.50 kb     26 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ST18 26 - 6330 115 1047 - Jandrig (2004

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Lymphoid/Immune spleen         Nervous brain         Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

Text	in the developing CNS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys)
	a SMC domain

HOMOLOGY

interspecies	ortholog to murine St18
	homolog to rattus St18

Homologene

FAMILY

myelin transcription factor 1 (Myt1) gene family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	suppressor of tumorogenicity (may be the same than TSG8E)
	having the potential to act as transcriptional regulator
	may have a regulatory function in a specific phase during neuronal differentiation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     breast carcinoma tumoral     --low   a 160 bp region within the promoter is hypermethylated in about 80p100 of the breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS