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FLASH GENE
Symbol OVOL2 contributors: mct/npt - updated : 27-01-2016
HGNC name ovo-like 2 (Drosophila)
HGNC id 15804
DNA
TYPE functioning gene
STRUCTURE 35.04 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text multiple transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1555 30 275 - 2009 19700410
4 - 1518 - 143 - 2009 19700410
3 - 1107 - 143 - 2009 19700410
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Skin/Tegumentskin   predominantly
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatocyte
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text expressed in myriad embryonic and postnatal tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C2H2-type zinc fingers
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to drosophila Ovo-like 2
    homolog to murine Ovl-2
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • Ovo family of evolutionarily conserved zinc finger transcription factors
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in meiotic/postmeiotic stages of spermatogenesis
  • essential for the survival and differentiation of female germ line cells (Unezaki 2007)
  • may play a critical role in vascular angiogenesis during early embryogenesis (Unezaki 2007)
  • key regulator of neural development and potential role in mammalian embryogenesis (Mackay 2006)
  • regulates independent yet related aspects of keratinocyte proliferation and differentiatio (Wells 2009)
  • contributes to the overall genetic program that maintains keratinocytes in a proliferation-competent and differentiation-resistant state, that of a stem/progenitor cell (Wells 2009)
  • may likeky play an important role in the XY body during spermatogenesis, possibly in the processes of XY body formation and meiotic sex chromosome inactivation
  • OVOL2 acts downstream of the BMP pathway in the cell fate decision between neuroectoderm and mesendoderm to ensure proper germ layer development
  • OVOL1, OVOL2 are gatekeepers of epithelial adhesion and differentiation by inhibiting progenitor-like traits and epithelial plasticity
  • GRHL2/OVOL2 network controlling CLDN4 and RAB25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
  • is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of HDAC1 to the TCF4-CTNNB1 complex
  • C2H2 zinc-finger transcription factor that regulates mesenchymal-to-epithelial transition
  • plays an important role during development
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS reproduction/sex
    text male germ cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • downstream target of OVOL1 (Teng 2007)
  • modulates NOTCH1 expression and downstream signaling (Wells 2009)
  • OVOL1 and OVOL2, are critical inducers of MET in human cancers
  • directly interacted with ETV2, but not with ETS1 or ETS2, in the nucleus
  • drives mesenchymal-to-epithelial transition (MET) by directly inhibiting EMT-inducing transcription factors, such as ZEB1
  • cell & other
    REGULATION
    repressed by OVOL1 (represses the activity of OVOL2 promoter in a DNA binding-dependent manner) (Teng 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s) PPCD1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS