basic FUNCTION
| involved in meiotic/postmeiotic stages of spermatogenesis |
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essential for the survival and differentiation of female germ line cells (Unezaki 2007) |
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may play a critical role in vascular angiogenesis during early embryogenesis (Unezaki 2007) |
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key regulator of neural development and potential role in mammalian embryogenesis (Mackay 2006) |
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regulates independent yet related aspects of keratinocyte proliferation and differentiatio (Wells 2009) |
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contributes to the overall genetic program that maintains keratinocytes in a proliferation-competent and differentiation-resistant state, that of a stem/progenitor cell (Wells 2009) |
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may likeky play an important role in the XY body during spermatogenesis, possibly in the processes of XY body formation and meiotic sex chromosome inactivation |
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OVOL2 acts downstream of the BMP pathway in the cell fate decision between neuroectoderm and mesendoderm to ensure proper germ layer development |
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OVOL1, OVOL2 are gatekeepers of epithelial adhesion and differentiation by inhibiting progenitor-like traits and epithelial plasticity |
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GRHL2/OVOL2 network controlling CLDN4 and RAB25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia |
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is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of HDAC1 to the TCF4-CTNNB1 complex |
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C2H2 zinc-finger transcription factor that regulates mesenchymal-to-epithelial transition |
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plays an important role during development |