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FLASH GENE
Symbol TUBGCP5 contributors: mct - updated : 13-10-2016
HGNC name tubulin, gamma complex associated protein 5
HGNC id 18600
DNA
TYPE functioning gene
STRUCTURE 40.49 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   cAMP
MAPPING cloned Y linked N status provisional
regionally located . located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3934 118.3 1024 - 2001 11694571
22 - 3442 118.3 1024 - 2001 11694571
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
Text expressed in fetal heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic motif is present in the N-terminus
  • HOMOLOGY
    interspecies ortholog to murine Tubgcp5
    Homologene
    FAMILY GCP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • necessary for microtublule nucleation at the centrosome
  • required for the formation or stability of gammaTuRC (gamma-tubulin ring complex) and the recruitment of gamma-tubulin to the spindle poles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of GSK3B in the proper formation of the mitotic spindles through an interaction with GCP5 (GSK3B regulates the localization of gammaTuRC, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles)
  • recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in congenital heart disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS