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FLASH GENE
Symbol TRIP4 contributors: mct - updated : 16-03-2016
HGNC name thyroid hormone receptor interactor 4
HGNC id 12310
DNA
TYPE functioning gene
STRUCTURE 67.50 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2057 - 581 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid     Mus musculus
Nervousbrainforebraincerebral cortex   Mus musculus
 gangliasensory gangliadorsal root   Mus musculus
 gangliaautonomic gangliasympathetic   Mus musculus
 spinal cord     Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved cysteine-rich Zn-chelating domain, which binds transcription factors
  • a conserved C-terminal domain, which harbors a RNA-binding PUA domain thought to be an ancient structural motif for RNA-protein interactions
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm
    text
  • nuclear protein that localized into the cytoplasm under conditions of serum deprivation
  • basic FUNCTION
  • initially identified as a transcriptional coactivator of the thyroid hormone receptor
  • TRIP4 and ASCC1 are indispensable for motor system development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of TRIP4 complex containing ASCC1, ASCC2 and ASCC3, the activating signal cointegrator 1 (ASC-1) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TRIP4 and SRF, which seemed to offer a functional link between genetic defect and disease phenotype because SRF is an essential transcription factor for muscle, nervous system, and bone development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCSMA2
    Susceptibility to Alzheimer disease
    Variant & Polymorphism SNP
  • rs74615166) is a novel genome-wide significant locus for Alzheimer disease risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS