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FLASH GENE
Symbol TIMM22 contributors: mct - updated : 23-05-2019
HGNC name translocase of inner mitochondrial membrane 22 homolog (yeast)
HGNC id 17317
DNA
TYPE functioning gene
STRUCTURE 5.03 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1691 20 194 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 stomach   highly
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemovary  predominantly
 male systemprostate   
 male systemtestis   
Respiratorylung   moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Timm22 (94.2 pc)
homolog to murine Timm22 (95.4 pc)
Homologene
FAMILY
  • TIM17/TIM22/TIM23 family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • mediating the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane
  • constituting the voltage-activated and signal-gated channel, in the TIM22 complex
  • forming a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps
  • majority of inner membrane protein precursors are synthesized in the cytosol, but precursors with a cleavable presequence are imported by the presequence translocase (TIMM23 complex), while other precursors containing internal targeting signals are imported by the carrier translocase (TIMM22 complex)
  • the carrier translocase (TIMM22 complex) inserts multispanning proteins into the inner membrane
  • TIMM22, TIMM23 import pathways depend on the presence of a membrane potential, which is generated by the activity of the respiratory chain
  • TIMM22 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text protein transport
    PATHWAY
    metabolism
    signaling
  • TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane (Hasson 2010)
  • a component
  • TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B
  • TIMM29 is required for the stability of the TIMM22 complex and functions in the assembly of TIMM22
  • TIMM29 is required for the structural integrity of the TIMM22 complex and for import of substrate proteins by the carrier translocase
  • AGK functions in a kinase-independent manner to maintain the integrity of the TIMM22 complex, where it facilitates the import and assembly of mitochondrial carrier proteins
  • VDAC1 interacts with carrier precursors arriving in the intermembrane space and recruits TIMM22 complexes, thus ensuring an efficient transfer of the precursors to the inner membrane translocase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TIMM22D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS