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FLASH GENE
Symbol TAF3 contributors: mct - updated : 29-04-2015
HGNC name TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
HGNC id 17303
DNA
TYPE functioning gene
STRUCTURE 196.04 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2790 - 929 - 2001 1143866
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PHD-finger domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TAF3 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in transcription regulation
  • TBPL2 and TAF3 are likely also required for hematopoiesis initiation
  • TBP-associated core promoter factor, that is highly enriched in ES cells
  • is required for endoderm lineage differentiation and prevents premature specification of neuroectoderm and mesoderm
  • role of TAF3 in mediating long-range chromatin regulatory interactions that safeguard the finely-balanced transcriptional programs underlying pluripotency
  • TAF3, and associated H3K4me3 interactions, have a direct role in gene-specific regulation within the TP53 network
  • H3K4me3, through TAF3 interactions, can act either independently or cooperatively with the TATA box to direct preinitiation complex (PIC) formation and transcription
  • is required for normal erythropoiesis and it might have a role in controlling the ratio between hemoglobin (Hb) and cell volume and in the dynamics of RBC maturation in healthy individuals
  • PHD-finger of TAF3 is important for rapid induction of target genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • three histone fold-containing interaction partners: TAF10, TAF8, and SUPT7L (Soutoglou 2005)
  • is an evolutionarily conserved negative regulator of TP53 transcription activation function
  • MYOD1 targets TAF3/TBPL2 to activate myogenin transcription
  • binding of the plant homeodomain (PHD) of TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor
  • H3K4me3, through interactions with TAF3, directs global TBP recruitment
  • TAF3 functions as an essential coactivator for TP53
  • TAF3 is required for transcription of the SPTA1 gene, encoding alpha spectrin, one of the proteins that link the plasma membrane to the actin cytoskeleton
  • TAF3 is a direct target of nuclear Phosphoinositides (PI)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS