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FLASH GENE
Symbol STARD6 contributors: mct - updated : 09-03-2017
HGNC name StAR-related lipid transfer (START) domain containing 6
HGNC id 18066
DNA
TYPE functioning gene
STRUCTURE 29.88 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 663 - 220 - 2006 18211099
EXPRESSION
Rna function STARD6 mRNA to be testis-specific
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus   Homo sapiens
 gangliasensory gangliadorsal root   Homo sapiens
 spinal cord     Homo sapiens
Reproductivemale systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
Text only in male germ-line cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a START domain
  • a hydrophobic sterol-binding pocket
  • a unique C-terminal extension
  • STARD4, STARD5 and STARD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization
  • HOMOLOGY
    interspecies homolog to murine Stard6
    Homologene
    FAMILY
  • StAR-related lipid transfer domain proteins family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • exhibits biological and biophysical properties that imply a role in steroidogenesis
  • might play an important role in lipid sensing of the nervous system
  • might have nuclear roles and contribute to subsequent formation of neuroprotective steroids after excitotoxic brain injury
  • testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells
  • overexpression of NXF2, FSIP1, and STARD6, in the absence of paclitaxel, increased the generation of multinucleated cells, a hallmark of aberrant mitosis
  • STAR and STARD6 bind cholesterol, but no cholesterol binding could be detected for STARD5
  • playing likely a previously unappreciated role in cholesterol homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS