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FLASH GENE
Symbol SPATA6 contributors: mct - updated : 06-09-2018
HGNC name spermatogenesis associated 6
HGNC id 18309
DNA
TYPE functioning gene
STRUCTURE 213.57 kb     15 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 5024 - 488 haploid cells 2015 26464655
13 - 4976 - 472 at low levels in testis, ovary, thymus and placenta 2015 26464655
12 - 4982 - 474 - 2015 26464655
derived from a proximal promoter between exons 7 and 8, and contains a translation initiation codon AUG
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C-Elegans Ncs-2
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • evolutionarily conserved testis-specific gene, encoding a protein required for formation of the segmented columns and the capitulum, two major structures of the sperm connecting piece essential for linking the developing flagellum to the head during late spermiogenesis
  • may play an important role in TGCTs (testicular germ cell tumors), and down-regulation of SPATA6 could lead to apoptosis of TGCTs
  • is a structural protein of the coupling apparatus specifically localized in the segmented columns and the capitulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is involved in myosin-based microfilament transport through interaction with myosin subunits
  • PMFBP1 cooperates with SUN5 and SPATA6 to connect sperm head to tail
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inactivation of Spata6 in mice leads to acephalic spermatozoa and male sterility