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FLASH GENE
Symbol RLN3 contributors: mct - updated : 29-11-2014
HGNC name relaxin 3 (H3)
HGNC id 17135
DNA
TYPE functioning gene
STRUCTURE 2.77 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 452 - 142 - 2003 14522968
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
Nervousbrain   predominantly
 braindiencephalonhypothalamus   Homo sapiens
Reproductivemale systemprostate    Homo sapiens
 male systemtestis    Homo sapiens
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY relaxin family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • may be playing a role in neuropeptide signaling processes
  • may act as a central signal linking nutritional status and reproductive function
  • hypothalamic neuropeptide that belongs to the insulin superfamily of peptides
  • may act as a hypothalamic signal to coordinate appetite, thyroid function, and reproductive status
  • neuropeptide that is implicated in the regulation of stress responses and memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component an A chain and a B chain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is thought to act in the brain via the RXFP3 receptor, although the RXFP1 receptor may also play a role
  • RLN3 exerts antifibrotic actions via RXFP1 and may enhance the collagen-inhibitory effects of RLN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    metabolic syndrome is associated with increased serum relaxin-3 levels in women
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be considered as a potential biomarker of metabolic syndrome
  • Therapy target
    ANIMAL & CELL MODELS