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FLASH GENE
Symbol RIT2 contributors: mct/npt - updated : 27/10/2008
HGNC name Ras-like without CAAX 2
HGNC id 10017
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 372.47 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1112 24.5 217 - Shi (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Rit2
Homologene
FAMILY
  • Ras subfamily of small guanine triphosphatases (GTPases)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GTPase activity
  • may play an important roles in the regulation of signaling pathways and cellular processes distinct from those controlled by Ras
  • neuron-specific small GTPase that is involved in downstream signaling of plexin B3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • calmodulin binding
  • interacting with PLXNB3
  • interaction with POU4F1 (functional interaction with POU4F1, demonstrating the role of RIT2 in modulating the activation of the POU4F1 regulated EGR1 promoter by the N-terminal domain of POU4F1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS