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FLASH GENE
Symbol RALY contributors: mct - updated : 16-09-2014
HGNC name RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow)
HGNC id 15921
DNA
TYPE functioning gene
STRUCTURE 89.53 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4790 - 305 - 2012 22994768
  • RALYL
  • expression of RALYL was significantly low in clear cell renal cell carcinoma and correlated with a poor prognosis in a large number of clinical samples
  • 9 - 4742 - 290 - 2012 22994768
    RALYS
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY heterogeneous nuclear ribonucleoproteins family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in many processes of mRNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • protein-protein interaction of RALY with EIF4A3, FMRP, and HNRNPC
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to facial pigmented spots during aging
  • Variant & Polymorphism other
  • genetic variations in RALY/ASIP, contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may be a potential therapeutic target as well as a poor prognostic factor, in clear cell renal cell carcinoma
    ANIMAL & CELL MODELS