basic FUNCTION
| novel protein ligand of the IRS1 PH domain that may serve to link IRS1 to the insulin receptor |
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regulates insulin receptor-stimulated SLC2A4 translocation in skeletal-muscle cells |
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may be involved in the induction of long-term gene expression programs to promote beta-cell mitogenesis and survival |
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regulates postnatal growth in an IGF11/AKT pathway-independent manner |
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PHIP can regulate the expression of upstream mediators of the IGF axis and downstream mediators of tumor cell invasion |
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is a molecular mediator of melanoma progression that also appears to function in the setting of a subset of triple-negative melanomas |