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FLASH GENE
Symbol NUTF2 contributors: mct - updated : 22-11-2011
HGNC name nuclear transport factor 2
HGNC id 13722
DNA
TYPE functioning gene
STRUCTURE 24.40 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 894 - 127 - 1998 9533885
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a functional site, present throughout the superfamily, and functioning as an nuclear pore complex binding site in NUTF2
  • HOMOLOGY
    Homologene
    FAMILY NUTF2 domain containing superfamily of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • regulates the distribution of RAN
  • essential regulator of the RAN distribution in living cells and NUTF2-mediated RAN nuclear import is required for NLS-dependent protein import
  • NUTF2 and RAN control nuclear import of the filamentous actin capping protein CAPG
  • potential mediator of retinal vasculature integrity, and may act by altering VEGFA expression, thereby influencing the development of diabetic retinopathy in patients with diabetes mellitus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind nuclear pore complex proteins and the GDP form of RAN
  • RAN is an import cargo of NUTF2
  • interaction with XPO6 (reduction of its activity leads to actin accumulation via failure of RANGTP restoration and NUTF2 sequestration in the nuclei of senescent cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS