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FLASH GENE
Symbol NSFL1C contributors: mct - updated : 14-03-2015
HGNC name NSFL1 (p97) cofactor (p47)
HGNC id 15912
DNA
TYPE functioning gene
STRUCTURE 25.53 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3568 40 368 - 1998 9824302
8 - 3475 - 339 - 1998 9824302
10 - 3574 - 372 - 1998 9824302
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineplacenta    
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one UBX domain
HOMOLOGY
interspecies homolog to murine LOC381642
homolog to rattus p47
Homologene
FAMILY
CATEGORY adaptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,intermed filament
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • VCIP1 and NSFL1C are shown to function in Golgi
  • and ER assembly
  • localization and phosphorylation of NSFL1C are important for Golgi disassembly-assembly during the cell cycle
  • essential factor for Golgi membrane fusion
  • is critical for negatively regulating stimulation-induced IKK activation in a manner that is mechanistically distinct from the previously characterized negative regulators, such as TNFAIP3 and CYLD
  • UBXN2B/NSFL1C adaptors of VCP regulate mitosis by limiting the centrosomal recruitment of AURKA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VCP-binding protein, functions in Golgi membrane fusion together with VCP and VCPIP1, another VCP-binding protein
  • associates with the IKBKG subunit of the IKB kinase (IKK) complex upon TNF or IL1 stimulation, and inhibits IKK activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS