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FLASH GENE
Symbol NEK11 contributors: SGE/npt - updated : 08-06-2010
HGNC name NIMA (never in mitosis gene a)- related kinase 11
HGNC id 18593
DNA
TYPE functioning gene
STRUCTURE 323.58 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing 2963 74.1 645 - Noguchi (2002)
  • isoform 1
  • NEK11L
  • 15 splicing 2107 54 470 - Noguchi (2002)
  • isoform 2
  • NEK11S
  • - - 2793 68.7 599 - Noguchi (2002)
  • isoform 3
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecaecumappendix vermicularlowly
    Endocrinepancreas    
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrainhindbraincerebellum lowly
    Reproductivefemale systemuterus  lowly
    Respiratorylung   lowly
     respiratory tracttrachea  lowly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S, G2, checkpoint, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one protein kinase domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Nek11 (76.6pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having a protein serine/threonine kinase activity
  • critical kinase triggering CDC25A degradation by directly phosphorylating it and thus leading to its polyubiquitylation and degradation (Sorensen 2010)
  • has a role in S phase checkpoint downstream of ATR/ATM signaling (Noguchi 2002)
  • phosphorylating histone H1, H2A, H3, H2B and H4
  • NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • nucleolar complex formed by NEK11 and NEK2A, increased in G1/S arrested cells (Noguchi 2004)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • activity enhanced by Mn2+
  • ATP
  • protein
  • histone H1, histone H2A, histone H3 (H2B,H4)
  • MBP
  • associating with NEK2A (Noguchi 2004)
  • cell & other
    REGULATION
    activated by DNA replication and genotoxic stresses
    phosphorylation on ser273 by CHEK1 (Sorensen 2010)
    inhibited by Zn2+, NaCl
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    expression increased during colon cancer development (Sorensen 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target inhibition of NEK11 forces checkpoint-arrested cells into mitosis and cell death, and thus is a potential target for the development of novel anticancer drugs (Sorensen 2010)
    ANIMAL & CELL MODELS