basic FUNCTION
| having a protein serine/threonine kinase activity |
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critical kinase triggering CDC25A degradation by directly phosphorylating it and thus leading to its polyubiquitylation and degradation (Sorensen 2010) |
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has a role in S phase checkpoint downstream of ATR/ATM signaling (Noguchi 2002) |
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phosphorylating histone H1, H2A, H3, H2B and H4 |
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NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response |