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FLASH GENE
Symbol NASP contributors: mct - updated : 09-09-2013
HGNC name nuclear autoantigenic sperm protein (histone-binding)
HGNC id 7644
DNA
TYPE functioning gene
STRUCTURE 34.92 kb     15 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing initiation site 3302 85.2 788 testis, spermatocytes, spermatid, spermatozoid 2012 2196553
  • isoform 2 tNASP, testicular NASP
  • characterization of a sperm NASP
  • critical for the survival of prostate cancer cells, suggesting that targeting tNASP expression can lead to a new approach for prostate cancer treatment
  • its role is to provide the functional link between linker histones and cell cycle progression during meiosis
  • 14 splicing initiation site 2294 - 449 all mitotic cells (adult embryonic) during five phases 2012 2196553
  • isoform 3 sNASP, somatic NASP
  • characterization of the histone H1-binding protein as a cell-cycle regulated somatic protein
  • possesses a unique binding specificity in that it forms specific complexes with both histone H1 and histones H3/H4
  • efficiently promoted the assembly of nucleosomes containing the conventional H3.1, H3.2, H3.3, or centromere-specific CENPA
  • - splicing initiation site 3396 - 790 - 2012 2196553
    13 - 3109 - 724 - 2012 2196553
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • TRP1-2-3 (tetratricopeptid) repeats
  • from coiled coil
  • glu-rich (acidic)
  • leucine-zipper
  • nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to murine Nasp
    homolog to C.elegans F58G11.1A
    homolog to xenopus N11N2
    Homologene
    FAMILY nuclear autoantigenic sperm protein (NASP) family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text tNASP : Golgi and acrosome nucleus, 5NASP:nuclear localization
    basic FUNCTION
  • transporting histones into the nucleus of dividing cells (isoform 3)
  • directly promotes nucleosome assembly, providing compelling evidence that sNASP is a bona fide histone chaperone for H3.H4
  • specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain
  • unique genuine chaperone for histone H1
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • GTP
  • protein
  • binding to H1 histones
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • TRA2B is involved in splicing processes of NASP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS