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FLASH GENE

Symbol

MAN1C1

contributors: npt/ - updated : 04-09-2004

HGNC name	mannosidase, alpha, class 1C, member 1
HGNC id	19080

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	167.30 kb     15 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MAN1C1 14 - 3201 70.8 630 - Hosokawa (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       liver         Lymphoid/Immune spleen           thymus         Nervous brain         Reproductive female system ovary         male system prostate         male system testis       Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cytoplasmic domain
	a transmembrane domain
	a luminal domain
	two N glycosylation sites
	a proline rich stem region
	the catalytic site

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

glycosyl hydrolase 47 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	involved in the hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the
	oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
	involved in the maturation of Asn-linked oligosaccharides

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

N-glycosylation

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS